diff --git a/.gitignore b/.gitignore
index 1a34795..7e6e659 100644
--- a/.gitignore
+++ b/.gitignore
@@ -21,3 +21,4 @@
 /pyo3-0.21.1.crate
 /pyo3-0.21.2.crate
 /pyo3-0.22.0.crate
+/pyo3-0.22.2.crate
diff --git a/0001-Make-unsafe-subinterpreter-support-available-via-cfg.patch b/0001-Make-unsafe-subinterpreter-support-available-via-cfg.patch
new file mode 100644
index 0000000..ffcdfb6
--- /dev/null
+++ b/0001-Make-unsafe-subinterpreter-support-available-via-cfg.patch
@@ -0,0 +1,25 @@
+From d59176bc05aa37838fd4a8dd253f47c962f61118 Mon Sep 17 00:00:00 2001
+From: Fabio Valentini <decathorpe@gmail.com>
+Date: Tue, 23 Jul 2024 14:41:04 +0200
+Subject: [PATCH] Make unsafe subinterpreter support available via cfg flag
+
+---
+ src/impl_/pymodule.rs | 2 +-
+ 1 file changed, 1 insertion(+), 1 deletion(-)
+
+diff --git a/src/impl_/pymodule.rs b/src/impl_/pymodule.rs
+index b05652b..94555ff 100644
+--- a/src/impl_/pymodule.rs
++++ b/src/impl_/pymodule.rs
+@@ -107,7 +107,7 @@ impl ModuleDef {
+         // that static data is not reused across interpreters.
+         //
+         // PyPy does not have subinterpreters, so no need to check interpreter ID.
+-        #[cfg(not(any(PyPy, GraalPy)))]
++        #[cfg(not(any(PyPy, GraalPy, pyo3_unsafe_allow_subinterpreters)))]
+         {
+             // PyInterpreterState_Get is only available on 3.9 and later, but is missing
+             // from python3.dll for Windows stable API on 3.9
+-- 
+2.45.2
+
diff --git a/0001-fix-regression-in-128-bit-number-conversions.patch b/0001-fix-regression-in-128-bit-number-conversions.patch
deleted file mode 100644
index 6d8d879..0000000
--- a/0001-fix-regression-in-128-bit-number-conversions.patch
+++ /dev/null
@@ -1,54 +0,0 @@
-From 0654258b18d314c83d6a3e78c4030d22b6b3ea75 Mon Sep 17 00:00:00 2001
-From: Fabio Valentini <decathorpe@gmail.com>
-Date: Wed, 26 Jun 2024 18:52:08 +0200
-Subject: [PATCH] fix regression in 128-bit number conversions
-
----
- src/conversions/std/num.rs | 23 +++++++++++++----------
- 1 file changed, 13 insertions(+), 10 deletions(-)
-
-diff --git a/src/conversions/std/num.rs b/src/conversions/std/num.rs
-index effe7c7..1304e73 100644
---- a/src/conversions/std/num.rs
-+++ b/src/conversions/std/num.rs
-@@ -238,15 +238,18 @@ mod fast_128bit_int_conversion {
-                         unsafe { ffi::PyNumber_Index(ob.as_ptr()).assume_owned_or_err(ob.py())? };
-                     let mut buffer = [0u8; std::mem::size_of::<$rust_type>()];
-                     #[cfg(not(Py_3_13))]
--                    crate::err::error_on_minusone(ob.py(), unsafe {
--                        ffi::_PyLong_AsByteArray(
--                            num.as_ptr() as *mut ffi::PyLongObject,
--                            buffer.as_mut_ptr(),
--                            buffer.len(),
--                            1,
--                            $is_signed.into(),
--                        )
--                    })?;
-+                    {
-+                        crate::err::error_on_minusone(ob.py(), unsafe {
-+                            ffi::_PyLong_AsByteArray(
-+                                num.as_ptr() as *mut ffi::PyLongObject,
-+                                buffer.as_mut_ptr(),
-+                                buffer.len(),
-+                                1,
-+                                $is_signed.into(),
-+                            )
-+                        })?;
-+                        Ok(<$rust_type>::from_le_bytes(buffer))
-+                    }
-                     #[cfg(Py_3_13)]
-                     {
-                         let mut flags = ffi::Py_ASNATIVEBYTES_NATIVE_ENDIAN;
-@@ -272,8 +275,8 @@ mod fast_128bit_int_conversion {
-                                 "Python int larger than 128 bits",
-                             ));
-                         }
-+                        Ok(<$rust_type>::from_ne_bytes(buffer))
-                     }
--                    Ok(<$rust_type>::from_ne_bytes(buffer))
-                 }
- 
-                 #[cfg(feature = "experimental-inspect")]
--- 
-2.45.2
-
diff --git a/pyo3-fix-metadata.diff b/pyo3-fix-metadata.diff
index e5f22f3..fa30a96 100644
--- a/pyo3-fix-metadata.diff
+++ b/pyo3-fix-metadata.diff
@@ -1,5 +1,5 @@
---- pyo3-0.22.0/Cargo.toml	1970-01-01T00:00:01+00:00
-+++ pyo3-0.22.0/Cargo.toml	2024-06-25T10:43:21.348671+00:00
+--- pyo3-0.22.2/Cargo.toml	1970-01-01T00:00:01+00:00
++++ pyo3-0.22.2/Cargo.toml	2024-07-23T12:35:05.486015+00:00
 @@ -239,7 +239,6 @@
      "serde",
      "smallvec",
diff --git a/rust-pyo3.spec b/rust-pyo3.spec
index 9abbdc4..a6e1513 100644
--- a/rust-pyo3.spec
+++ b/rust-pyo3.spec
@@ -5,7 +5,7 @@
 %global crate pyo3
 
 Name:           rust-pyo3
-Version:        0.22.0
+Version:        0.22.2
 Release:        %autorelease
 Summary:        Bindings to Python interpreter
 
@@ -15,8 +15,10 @@ Source:         %{crates_source}
 # Manually created patch for downstream crate metadata changes
 # * drop MSVC- and MinGW-only features
 Patch:          pyo3-fix-metadata.diff
-# https://github.com/PyO3/pyo3/issues/4290
-Patch:          0001-fix-regression-in-128-bit-number-conversions.patch
+
+# * make unsafe subinterpreter support available via cfg flag:
+#   https://bugzilla.redhat.com/show_bug.cgi?id=2298403
+Patch:          0001-Make-unsafe-subinterpreter-support-available-via-cfg.patch
 
 BuildRequires:  cargo-rpm-macros >= 24
 
diff --git a/sources b/sources
index d72404a..91e9d55 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (pyo3-0.22.0.crate) = 44e0237fd3a8d4c7b082c48a5c8a52d8f4cc4673d134f680e29504bb46d870015fa210da34de4c1998defbcd4afdf2aaea4e148fbe093e4b2c8b0d064cd48da4
+SHA512 (pyo3-0.22.2.crate) = e8bae09059f50ffe477dad44499cedeaf3a734665f0fd8e8bd4b44f48578d21e4bdb8d55ceea00c5a27da750761842ddf89cfcecdecb2e7a4a17ab192259be9c