diff --git a/.gitignore b/.gitignore
index 77e145d..39e0a35 100644
--- a/.gitignore
+++ b/.gitignore
@@ -3,3 +3,4 @@
 /pycryptodomex-3.9.4.tar.gz
 /pycryptodomex-3.9.6.tar.gz
 /pycryptodomex-3.9.7.tar.gz
+/pycryptodomex-3.10.1.tar.gz
diff --git a/python-pycryptodomex-3.10.1-use_external_libtomcrypt.patch b/python-pycryptodomex-3.10.1-use_external_libtomcrypt.patch
new file mode 100644
index 0000000..9e45b26
--- /dev/null
+++ b/python-pycryptodomex-3.10.1-use_external_libtomcrypt.patch
@@ -0,0 +1,43 @@
+diff -up ./setup.py.bak ./setup.py
+--- ./setup.py.bak	2021-02-08 22:14:54.000000000 +0100
++++ ./setup.py	2021-02-09 15:55:53.785892041 +0100
+@@ -367,12 +367,14 @@ ext_modules = [
+         sources=["src/CAST.c"],
+         py_limited_api=True),
+     Extension("Crypto.Cipher._raw_des",
+-        include_dirs=['src/', 'src/libtom/'],
++        include_dirs=['src/'],
+         sources=["src/DES.c"],
++        extra_link_args=["-ltomcrypt"],
+         py_limited_api=True),
+     Extension("Crypto.Cipher._raw_des3",
+-        include_dirs=['src/', 'src/libtom/'],
++        include_dirs=['src/'],
+         sources=["src/DES3.c"],
++        extra_link_args=["-ltomcrypt"],
+         py_limited_api=True),
+     Extension("Crypto.Util._cpuid_c",
+         include_dirs=['src/'],
+@@ -410,8 +412,9 @@ ext_modules = [
+         sources=["src/ARC4.c"],
+         py_limited_api=True),
+     Extension("Crypto.Cipher._Salsa20",
+-        include_dirs=['src/', 'src/libtom/'],
++        include_dirs=['src/'],
+         sources=["src/Salsa20.c"],
++        extra_link_args=["-ltomcrypt"],
+         py_limited_api=True),
+     Extension("Crypto.Cipher._chacha20",
+         include_dirs=['src/'],
+diff -up ./src/DES.c.bak ./src/DES.c
+--- ./src/DES.c.bak	2021-02-08 22:14:54.000000000 +0100
++++ ./src/DES.c	2021-02-09 15:55:53.785892041 +0100
+@@ -39,7 +39,7 @@ FAKE_INIT(raw_des3)
+ 
+ /* Include the actial DES implementation */
+ #define LTC_NO_PROTOTYPES
+-#include "libtom/tomcrypt_des.c"
++#include <tomcrypt.h>
+ 
+ struct block_state {
+     symmetric_key sk;
diff --git a/python-pycryptodomex-3.7.0-sphinx.patch b/python-pycryptodomex-3.7.0-sphinx.patch
deleted file mode 100644
index bc83b2c..0000000
--- a/python-pycryptodomex-3.7.0-sphinx.patch
+++ /dev/null
@@ -1,27 +0,0 @@
-diff -up ./Doc/conf.py.bak ./Doc/conf.py
---- ./Doc/conf.py.bak	2018-10-27 23:08:03.000000000 +0200
-+++ ./Doc/conf.py	2018-11-17 15:34:58.392588884 +0100
-@@ -20,6 +20,10 @@ print sys.path
- # Mock existence of native modules
- from Crypto.Util import _raw_api
- 
-+from distutils.version import LooseVersion
-+
-+import sphinx
-+
- class MockLib(object):
-     ghash_portable = None
-     ghash_expand_portable = None
-@@ -40,7 +44,11 @@ _raw_api.load_pycryptodome_raw_lib = lam
- 
- # Add any Sphinx extension module names here, as strings. They can be extensions
- # coming with Sphinx (named 'sphinx.ext.*') or your custom ones.
--extensions = [ 'sphinx.ext.autodoc', 'sphinx.ext.napoleon',
-+if LooseVersion(sphinx.__version__) <= LooseVersion('1.2'):
-+    napoleon_ext = 'sphinxcontrib.napoleon'
-+else:
-+    napoleon_ext = 'sphinx.ext.napoleon'
-+extensions = [ 'sphinx.ext.autodoc', napoleon_ext,
-         'sphinx.ext.mathjax' ]
- 
- # Add any paths that contain templates here, relative to this directory.
diff --git a/python-pycryptodomex-3.7.3-cflags.patch b/python-pycryptodomex-3.7.3-cflags.patch
deleted file mode 100644
index d5c9920..0000000
--- a/python-pycryptodomex-3.7.3-cflags.patch
+++ /dev/null
@@ -1,11 +0,0 @@
-diff -up ./compiler_opt.py.bak ./compiler_opt.py
---- ./compiler_opt.py.bak	2019-01-19 22:52:55.000000000 +0100
-+++ ./compiler_opt.py	2019-02-15 16:40:42.739281229 +0100
-@@ -334,7 +334,6 @@ def set_compiler_options(package_root, e
- 
-     # Options specific to GCC and CLANG
-     if clang or gcc:
--        extra_cc_options.append('-O3')
-         if compiler_supports_sse2_with_x86intrin_h():
-             extra_cc_options.append('-msse2')
-             extra_macros.append(("HAVE_X86INTRIN_H", None))
diff --git a/python-pycryptodomex-3.7.3-use_external_libtomcrypt.patch b/python-pycryptodomex-3.7.3-use_external_libtomcrypt.patch
deleted file mode 100644
index 97bd2e6..0000000
--- a/python-pycryptodomex-3.7.3-use_external_libtomcrypt.patch
+++ /dev/null
@@ -1,45 +0,0 @@
-diff -up ./setup.py.bak ./setup.py
---- ./setup.py.bak	2019-01-19 22:52:55.000000000 +0100
-+++ ./setup.py	2019-02-15 15:29:46.960976879 +0100
-@@ -367,11 +367,13 @@ ext_modules = [
-         include_dirs=['src/'],
-         sources=["src/CAST.c"]),
-     Extension("Crypto.Cipher._raw_des",
--        include_dirs=['src/', 'src/libtom/'],
--        sources=["src/DES.c"]),
-+        include_dirs=['src/'],
-+        sources=["src/DES.c"],
-+        extra_link_args=["-ltomcrypt"]),
-     Extension("Crypto.Cipher._raw_des3",
--        include_dirs=['src/', 'src/libtom/'],
--        sources=["src/DES3.c"]),
-+        include_dirs=['src/'],
-+        sources=["src/DES3.c"],
-+        extra_link_args=["-ltomcrypt"]),
-     Extension("Crypto.Util._cpuid_c",
-         include_dirs=['src/'],
-         sources=['src/cpuid.c']),
-@@ -400,8 +402,9 @@ ext_modules = [
-         include_dirs=['src/'],
-         sources=["src/ARC4.c"]),
-     Extension("Crypto.Cipher._Salsa20",
--        include_dirs=['src/', 'src/libtom/'],
--        sources=["src/Salsa20.c"]),
-+        include_dirs=['src/'],
-+        sources=["src/Salsa20.c"],
-+        extra_link_args=["-ltomcrypt"]),
-     Extension("Crypto.Cipher._chacha20",
-         include_dirs=['src/'],
-         sources=["src/chacha20.c"]),
-diff -up ./src/DES.c.bak ./src/DES.c
---- ./src/DES.c.bak	2019-01-19 22:52:55.000000000 +0100
-+++ ./src/DES.c	2019-02-15 15:30:27.014967034 +0100
-@@ -39,7 +39,7 @@ FAKE_INIT(raw_des3)
- 
- /* Include the actial DES implementation */
- #define LTC_NO_PROTOTYPES
--#include "libtom/tomcrypt_des.c"
-+#include <tomcrypt.h>
- 
- struct block_state {
-     symmetric_key sk;
diff --git a/python-pycryptodomex.spec b/python-pycryptodomex.spec
index 4d75183..a6dd908 100644
--- a/python-pycryptodomex.spec
+++ b/python-pycryptodomex.spec
@@ -31,7 +31,7 @@ with the PyCrypto library.
 %global _with_tests 1
 
 Name:           python-%{srcname}
-Version:        3.9.7
+Version:        3.10.1
 Release:        1%{?dist}
 Summary:        A self-contained cryptographic library for Python
 
@@ -41,9 +41,7 @@ License:        BSD and Public Domain
 URL:            http://www.pycryptodome.org/
 Source0:        https://github.com/Legrandin/pycryptodome/archive/v%{version}/%{srcname}-%{version}.tar.gz
 # Use external libtomcrypt library
-Patch0:         %{name}-3.7.3-use_external_libtomcrypt.patch
-# Fix documentation build with Sphinx <= 1.2, especially on EL
-Patch1:         %{name}-3.7.0-sphinx.patch
+Patch0:         %{name}-3.10.1-use_external_libtomcrypt.patch
 
 BuildRequires:  gcc
 BuildRequires:  libtomcrypt-devel
@@ -115,12 +113,6 @@ touch .separate_namespace
 # Install man pages
 install -Dpm 0644 Doc/_build/man/pycryptodome.1 $RPM_BUILD_ROOT%{_mandir}/man1/pycryptodome.1
 
-# Fix permissions
-%if 0%{_with_python2}
-chmod 0755 $RPM_BUILD_ROOT%{python2_sitearch}/Cryptodome/SelfTest/PublicKey/test_vectors/ECC/gen_ecc_p256.sh
-%endif
-chmod 0755 $RPM_BUILD_ROOT%{python3_sitearch}/Cryptodome/SelfTest/PublicKey/test_vectors/ECC/gen_ecc_p256.sh
-
 
 %check
 %if 0%{?_with_tests}
@@ -150,6 +142,9 @@ chmod 0755 $RPM_BUILD_ROOT%{python3_sitearch}/Cryptodome/SelfTest/PublicKey/test
 
 
 %changelog
+* Tue Aug 03 2021 Mohamed El Morabity <melmorabity@fedoraproject.org> - 3.10.1-1
+- Update to 3.10.1
+
 * Fri Feb 21 2020 Mohamed El Morabity <melmorabity@fedoraproject.org> - 3.9.7-1
 - Update to 3.9.7
 
diff --git a/sources b/sources
index b3a7387..3545a2c 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (pycryptodomex-3.9.7.tar.gz) = 3b0361d7afc772d9dec068b42d6a36732faeec55b7317cbe31fa86d65069b314c735fcfce03e68381d86f64dcb7abd751b0225c05f760631266063c1664fca4c
+SHA512 (pycryptodomex-3.10.1.tar.gz) = 4c7e7e989d5363064e7e184f6b00a174045e03916cdf1199626afd7fe75eb5efcd13888ecdee607b974e96faad465694b384eb6d91edb8de1d0277ad71888c52