diff --git a/epel-rpm-macros.spec b/epel-rpm-macros.spec
index f7cb5b3..fdf354a 100644
--- a/epel-rpm-macros.spec
+++ b/epel-rpm-macros.spec
@@ -1,6 +1,6 @@
 Name:           epel-rpm-macros
 Version:        8
-Release:        24
+Release:        25
 Summary:        Extra Packages for Enterprise Linux RPM macros
 
 Group:          System Environment/Base
@@ -72,6 +72,9 @@ install -Dpm 644 %{SOURCE150} \
 
 
 %changelog
+* Tue Oct 26 2021 Tomas Orsava <torsava@redhat.com> - 8-25
+- Define a new macros %%python_wheel_dir and %%python_wheel_pkg_prefix
+
 * Wed Sep  1 2021 Michel Alexandre Salim <salimma@fedoraproject.org> - 8-24
 - Fix macros.build-constraints' %%limit_build
   - number of CPUs will never be set to less than 1
diff --git a/macros.epel-rpm-macros b/macros.epel-rpm-macros
index c693891..6c08775 100644
--- a/macros.epel-rpm-macros
+++ b/macros.epel-rpm-macros
@@ -115,6 +115,20 @@
 %undefine __pythondist_requires \
 %{nil}
 
+# Define where Python wheels will be stored and the prefix of -wheel packages
+# - In Fedora we want wheel subpackages named e.g. `python-pip-wheel` that
+#   install packages into `/usr/share/python-wheels`. Both names are not
+#   versioned, because they're used by all Python 3 stacks.
+# - In RHEL we want wheel packages named e.g. `python3-pip-wheel` and
+#   `python3.11-pip-wheel` that install packages into similarly versioned
+#   locations. We want each Python stack in RHEL to have their own wheels,
+#   because the main python3 wheels (which we can't upgrade) will likely be
+#   quite old by the time we're adding new alternate Python stacks.
+# - In ELN we want to follow Fedora, because builds for ELN and Fedora rawhide
+#   need to be interoperable.
+%python_wheel_pkg_prefix python%{?rhel:%{!?eln:%{python3_pkgversion}}}
+%python_wheel_dir %{_datadir}/%{python_wheel_pkg_prefix}-wheels
+
 # gpgverify verifies signed sources. There is documentation in the script.
 %gpgverify(k:s:d:) %{lua:
 local script = rpm.expand("%{_rpmconfigdir}/gpgverify ")